HBIG should be given within how many hours after birth to neonates born to HBsAg-positive mothers?

• A. Within 6 hours
• B. Within 24 hours
• C. Within 48 hours
• D. Within 12 hours

Answer: (D)

The main idea is that newborns at risk for hepatitis B transmission receive both immediate passive protection and early active protection, started right at birth. HBIG provides immediate anti-HBs antibodies, while the hepatitis B vaccine begins the infant’s own immune response. Because the risk of transmission is highest at birth, HBIG should be given as soon as possible after birth, with the first vaccine dose, and the target window is within 12 hours. Delaying beyond 12 hours lowers effectiveness, and options outside this window (such as 24 or 48 hours) are not as optimal. Administration within 12 hours offers the best chance to prevent mother-to-child transmission.