How long should Zidovudine prophylaxis be continued in the exposed newborn?

• A. Six weeks
• B. One week
• C. Three months
• D. Six months

Answer: (A)

The main idea is protecting the newborn from HIV transmission by giving neonatal Zidovudine for a set period after birth. Zidovudine prophylaxis is started soon after birth to inhibit viral replication during the early period when exposure from the mother is most likely to lead to infection. Continuing the drug for six weeks provides sustained protection through the critical early weeks of life, balancing effectiveness with safety and practicality. Shorter durations, like one week, wouldn’t cover the whole high-risk window, while much longer courses aren’t routinely required and can add unnecessary exposure. Therefore six weeks is the recommended duration for Zidovudine prophylaxis in the HIV-exposed newborn.