Isolated syndactyly shows which inheritance pattern?

• A. Autosomal recessive
• B. Autosomal dominant
• C. Sex-linked dominant
• D. X-linked recessive

Answer: (B)

Isolated syndactyly is typically autosomal dominant. A single mutant allele is enough to produce the trait, so it often appears in multiple generations with about a 50% risk to each child of an affected parent. There is no sex bias with autosomal traits, so males and females are affected equally, which fits isolated syndactyly patterns. While de novo mutations can occur and explain a case with no family history, the familial pattern when present aligns with autosomal dominant inheritance.