Palivizumab is administered by which route?

• A. Intramuscular (IM)
• B. Oral
• C. Subcutaneous (SC)
• D. Intravenous (IV)

Answer: (A)

Palivizumab must be given by injection into muscle because it is a protein biologic; if taken by mouth, it would be destroyed in the digestive tract and not provide protection. Intramuscular administration provides reliable systemic absorption and is practical for the monthly dosing used during RSV season. It is not given orally, and while some biologics are given subcutaneously or intravenously, palivizumab is conventionally administered intramuscularly (typically in the thigh of infants).