Which combination of features best describes Apert syndrome?

• A. Craniosynostosis, maxillary hypoplasia, and symmetric syndactyly
• B. Craniosynostosis and macrocephaly
• C. Midface hypoplasia with no syndactyly
• D. Normal craniofacial features

Answer: (A)

Apert syndrome is defined by premature fusion of skull sutures (craniosynostosis) with midface (maxillary) hypoplasia and usually symmetric syndactyly of the hands and feet. The combination that includes craniosynostosis, maxillary hypoplasia, and symmetric syndactyly best matches these hallmark features. Other options miss one of these core clues—such as lacking syndactyly or describing features not typical of Apert (like macrocephaly) or normal facial features. This triad also explains the clinical concerns you’d watch for, including head shape changes and the need for hand and craniofacial management.