Which disorder is commonly associated with bilateral renal agenesis?

• A. Meckel's Syndrome
• B. Potter Sequence
• C. Turner’s Syndrome
• D. Down Syndrome

Answer: (B)

Bilateral renal agenesis stops fetal urine production, the main source of amniotic fluid. Without enough amniotic fluid, the fetus becomes severely oligohydramnios, which leads to a recognizable pattern of anomalies called Potter sequence. The key features arise from the chronic compression and poor lung development: characteristic facial appearance from compression, limb deformities, and especially pulmonary hypoplasia due to the lack of cushioning fluid. Thus, bilateral renal agenesis is most commonly associated with Potter sequence. The other conditions listed involve different primary problems—Turner’s and Down syndromes are chromosomal disorders, and Meckel (Meckel-Gruber) syndrome is a distinct lethal condition with other renal and CNS malformations, not the classic association with bilateral renal agenesis.