Which of the following describes Potter sequence?

• A. Eagle-Barrett syndrome
• B. Fanconi syndrome
• C. Potter sequence
• D. Beckwith-Wiedemann syndrome

Answer: (C)

Potter sequence is a pattern of anomalies caused by severe oligohydramnios, usually from renal agenesis or significant urinary tract abnormalities. The lack of amniotic fluid compresses the fetus, leading to pulmonary hypoplasia and characteristic facial and limb findings from restricted fetal movement. This sequence describes the cascade starting with reduced amniotic fluid and culminating in the observed neonatal features. It differs from Eagle-Barrett syndrome, which centers on abdominal wall weakness and urinary tract issues; from Fanconi syndrome, which is a proximal renal tubule dysfunction with metabolic disturbances; and from Beckwith-Wiedemann syndrome, an overgrowth condition with macroglossia and omphalocele.