Which of the following is associated with genitourinary abnormalities, deficiency of abdominal wall structure, and cryptorchidism?

• A. Cloacal exstrophy
• B. Hypospadias
• C. Congenital nephrotic syndrome
• D. Eagle-Barrett syndrome

Answer: (D)

Prune Belly syndrome, also called Eagle-Barrett syndrome, is defined by a triad: deficient abdominal wall musculature, genitourinary abnormalities, and cryptorchidism. The lack of abdominal wall muscle leads to a loose, distended abdomen, while the GU tract malformations disrupt normal testicular descent, making undescended testes common. This combination of findings across abdominal wall, urinary system, and testes is characteristic, making this condition the best fit for the described associations.

Cloacal exstrophy involves bladder and intestinal defects with a different pattern of malformations and is not defined by the same abdominal-wall deficiency paired with cryptorchidism as a triad. Hypospadias is a single GU anomaly without the concomitant abdominal wall deficiency or cryptorchidism. Congenital nephrotic syndrome is a kidney disorder unrelated to the abdominal wall or the cryptorchidism component.