Which statement correctly describes epinephrine dosing for neonatal resuscitation?

• A. It is given intramuscularly at 0.5 mL
• B. It is given intravenously at 0.4-1.2 mL for a 4 kg infant
• C. It is given subcutaneously at 2 mL
• D. It is never used in neonates

Answer: (B)

In neonatal resuscitation, epinephrine is given IV/IO in a weight-based dose to improve perfusion during CPR. The recommended dose is 0.01–0.03 mg/kg, given every 3–5 minutes. Using a 1:10,000 solution (which is 0.1 mg/mL), this translates to 0.1 mL per kg to 0.3 mL per kg. For a 4 kg infant, that becomes about 0.4–1.2 mL per dose IV. This matches the option describing intravenous administration of 0.4–1.2 mL for a 4 kg infant.

The other options don’t fit the resuscitation protocol: intramuscular or subcutaneous routes and fixed volumes aren’t the standard approach in this setting, and epinephrine is indeed used in neonates during resuscitation, not avoided.